Publication date: Available online 20 September 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geißen, Melissa S. Boby, Bradley S. Sherborne, Derek S. Tan
Monthly Archives: October 2023
Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)
Publication date: Available online 29 September 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Jocelyn Wang, Kohki M. Nakafuku, Jeannie Ziff, Christine F. Gelin, Hadi Gholami, Aaron A. Thompson, Nathan K. Karpowich, Luis Limon, Heather R. Coate, Kelly L. Damm-Ganamet, Amy Y. Shih, Joanna C. Grant, Marjorie Côte, Puiying A. Mak, Heather A. Pascual, Marie-Laure Rives, James P. Edwards, Jennifer D. Venable, Hariharan Venkatesan, Zhicai Shi
Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1
Publication date: Available online 6 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Huaxing Shen, Nan Zhang, Xianglong Kong, Nan Wang, Hong-Gang Hu, Wei Cong, Chao Liu
5-HT<sub>6</sub> receptor antagonists. Design, synthesis, and structure–activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines
Publication date: Available online 6 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Michał Gałęzowski, Charles-Henry Fabritius, Ullamari Pesonen, Harri Salo, Marta Olszak-Płachta, Klaudia Czerwińska, Justyna Adamczyk, Marcin Król, Peteris Prusis, Magdalena Sieprawska-Lupa, Maciej Mikulski, Katja Kuokkanen, Radosław Obuchowicz, Timo Korjamo, Niina Jalava, Agnieszka Nikiforuk, Mateusz Nowak
Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors
Publication date: Available online 11 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Christopher W. Shrader, Daniel Foster, Yugesh Kharel, Tao Huang, Kevin R. Lynch, Webster L. Santos
Discovery and Characterisation of Quinazolines and 8-Azaquinazolines as NLRP3 Agonists with Oral Bioavailability in Mice
Publication date: Available online 12 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Daniel H. O' Donovan, David Baker, Giovanni Ciotta, Sébastien L. Degorce, Sylvain Demanze, Milly Dockerill, Leire Escudero-Ibarz, Lucy Ireland, Yumeng Mao, Martin J. Packer, James Robinson, Graeme Scarfe, Haoran Tang, Viia Valge-Archer
Discovery of <em>(E)-2-(Hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide</em> (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase
Publication date: Available online 12 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Avinash G Vishakantegowda, Berehe Solomon Girmay, Jin Soo Shin, Joo-Youn Lee, Sunjoo Ahn, Young-Sik Jung
Green synthesis and anti-biofilm activities of 3,5-disubstituted isoxazoline/isoxazole-linked secondary sulfonamide derivatives on <em>Pseudomonas aeruginosa</em>
Publication date: Available online 12 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Ayoub El Mahmoudi, Anne-Sophie Tareau, Magalie Barreau, Sylvie Chevalier, Chaimae Hourma, Luc Demange, Rachid Benhida, Khalid Bougrin
Design, synthesis and biological evaluation of 2-aminopyrimidine derivatives as potent FLT3 inhibitors
Publication date: Available online 12 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Xuanmin Lian, Yue Gao, Xuemei Li, Peipei Wang, Lexian Tong, Jia Li, Yubo Zhou, Tao Liu
Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents
Publication date: Available online 12 October 2023
Source: Bioorganic & Medicinal Chemistry Letters
Author(s): Yingcai Wang, Guangli Nie, Xingshun Wang, Wei Ge, Yandong Zhang