One-pot synthesis of thioethers from indoles and p-quinone methides using thiourea as a sulfur source

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01312J, Communication
Pradeep Kumar, Deepanshi Saxena, Rahul Maitra, Sidharth Chopra, T. Narender
A simple and efficient protocol has been developed to access thioethers by reacting indoles with p-quinone methides using thiourea as a sulfur source.
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Natural epoxyquinoids: isolation, biological activity and synthesis. An update

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01141K, Review Article
Vitaly A. Shcherbinin, Ekaterina R. Nasibullina, Elena Y. Mendogralo, Maxim G. Uchuskin
This review provides an updated outlook on the isolation of epoxyquinoids and an examination of their biological profile. Total, enantioselective synthesis, and the development of shorter approaches to construction of epoxyquinoids are addressed.
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Reductive cross-coupling of N-acyl pyrazole and nitroarene using tetrahydroxydiboron: synthesis of secondary amides

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01040F, Paper
Hayeon Moon, Sunwoo Lee
Acyl pyrazoles, in the presence of B2(OH)4, efficiently yield amides when reacted with nitro compounds. The method is versatile, tolerates diverse functional groups, and holds promise for diverse organic molecule synthesis.
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Organocatalytic allylic alkylation of alkyne-substituted MBH carbonates: access to quaternary carbon-containing 1,4-enynes

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01317K, Communication
Yu Li, Mei Wang, Rongrong Ma, Rui Niu, Haodong Wang, Yantu Zhang, Jun-Bing Lin
A DABCO-catalyzed allylic alkylation of alkyne-substituted MBH carbonates with nitromethane was realized, delivering a series of all-carbon quaternary center-containing 1,4-enynes.
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B(C6F5)3-catalyzed hydrogermylation of enones: a facile route to germacycles

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01402A, Communication
Jiangkun Xiong, Maying Yan, Lvnan Jin, Weihong Song, Lei Xiao, Dong Xu, Chunyang Zhai, Douglas W. Stephan, Jing Guo
Organogermacycles are prepared in good to excellent yields by B(C6F5)3 mediated domino hydrogermylation reaction of enones with dihydrogermanes.
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Regioselective [2 + 1] photocycloaddition of 2-pyridones with diazo compounds

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01354E, Communication
Fengya He, Ziyi Sun, Chenyue Li, Zibin Jiang, Hui Miao, Qinglin Li, Chenggui Wu
A novel strategy for the regioselective cyclopropanation of 2-pyridones under photocatalyst-free conditions, showing excellent regio- and stereo-selectivity, is reported.
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Organic photoredox catalyzed C(sp3)–H functionalization of saturated aza-heterocycles via a cross-dehydrogenative coupling reaction

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01438J, Communication
Yi-Fan Zhang, Han-Nan Chen, Yi Xiao, Zhencun Cui, Wei David Wang, Guo-Qiang Xu
A novel organic photoredox catalyzed CDC reaction of aza-heterocycles with various groups including indole, naphthol, phenol, pyrrole, furyl, nitromethyl, and cyano, was established, providing a concise way to access α-functionalized cyclic amines.
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Fluorescent styryl pyridine-N-oxide probes for imaging lipid droplets

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01365K, Paper
Yogesh Dubey, Paramasivam Mahalingavelar, Deeksha Rajput, Dipeshwari J. Shewale, Virupakshi Soppina, Sriram Kanvah
Sub-cellular imaging with styryl fluorophores: the zwitterion labels lipid droplets and the cation stains mitochondria.
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Recent Advances in Metal Directed C─H Amidation/Amination using Sulfonyl Azides and Phosphroyl Azides

Org. Biomol. Chem., 2023, Accepted Manuscript
DOI: 10.1039/D3OB01160G, Review Article
Krishna Rao M V, Karim Shaik , Shaik Ramjan Vali , Venkata Subba Reddy Basireddy
Transition metal-catalyzed C−N bond formation reactions have gained popularity as a method for constructing N-functionalized molecules by selectively transforming ubiquitous C-H bonds. This approach is particularly useful for synthesizing aminated...
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Efficient, multi-hundred-gram scale access to E3 ubiquitin ligase ligands for degrader development

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB00983A, Paper
Mark S. Cooper, Mark C. Norley, Simon Armitage, Joel O. Cresser-Brown, Anthony K. Edmonds, Sean Goggins, Jonathan P. Hopewell, Burhan Karadogan, Kevin A. Knights, Toby J. Nash, Catherine S. Oakes, William J. O'Neill, Simon J. Pridmore, Hannah J. Maple, Graham P. Marsh
Supporting degrader discovery programs in scale and scope: facile access to multi-hundred-gram quantities of the common E3 ligase ligands.
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