Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Qingna Jiang, Minghai Fu, Yuanling Tang, Ge Li, Guihui Tu, Xinhua Wu, Qiurong Wu, Xiuwang Huang, Jianhua Xu, Yang Liu, Lixian Wu
Monthly Archives: October 2023
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of 4-butyl-polyhydroxybenzophenone compounds against NAFLD
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Jiayu Song, Luyao Ren, Zhenzhu Ren, Xing Ren, Yang Qi, Yuxi Qin, Xiaohui Zhang, Yuan Ren, Yunlan Li
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Davide Moi, Davide Bonanni, Silvia Belluti, Pasquale Linciano, Andrea Citarella, Silvia Franchini, Claudia Sorbi, Carol Imbriano, Luca Pinzi, Giulio Rastelli
Discovery of antiviral SARS-CoV-2 main protease inhibitors by structure-guided hit-to-lead optimization of carmofur
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Koon Mook Kang, Yejin Jang, Sang Soo Lee, Mi Sun Jin, Chang-Duk Jun, Meehyein Kim, Yong-Chul Kim
Lead generation from <em>N</em>-[benzyl(4-phenylbutyl)carbamoyl]amino acid as a novel LPA<sub>1</sub> antagonist for the treatment of systemic sclerosis
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Yuki Kobayashi, Fumito Uneuchi, Takumi Naruse, Daisuke Matsuda, Lisa Okumura-Kitajima, Hiromitsu Kajiyama, Reiko Wada, Yuki Yonemoto, Koichiro Nakano, Hidetoh Toki, Shunsuke Kamigaso, Jyunya Yamagishi, Seiken Tokura, Hiroyuki Kakinuma, Shoichi Kuroda
Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating pathogenic bacteria in vitro and in vivo
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Qian Yu, Qiongna Cai, Wanxin Liang, Kewen Zhong, Jiayong Liu, Haizhou Li, Yongzhi Chen, Hongxia Li, Shanfang Fang, Rongcui Zhong, Shouping Liu, Shuimu Lin
Cantharidin analogue alleviates dextran sulfate sodium-induced colitis in mice by inhibiting the activation of NF-κB signaling
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Yihang Wu, Zixiu Liu, Zhenxiu He, Jumei Yi, Xingfang Qiao, Chunbin Tan, Yajing Xing, Yaobo Zeng, Dajian Yang, Junlin Yin, Baomin Fan, Guangzhi Zeng
Design, synthesis, and biological evaluation of novel HDAC/CD13 dual inhibitors for the treatment of cancer
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Geng Jia, Kangjing Qi, Baogeng Hou, Kairui Yue, Tongqiang Xu, Yuqi Jiang, Xiaoyang Li
Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis <em>in vitro</em> and <em>in vivo</em>
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Zhihao Chen, Devaneyan Joseph, Mina Ding, Swapnil Pandurang Bhujbal, Robin Prakash Sirvin Rajan, Eunae Kim, Sang-wook Park, Sunwoo Lee, Tae-Hoon Lee
Synthesis of 1,3,5-triphenyl-1,2,4-triazole derivatives and their neuroprotection by anti-oxidative stress and anti-inflammation and protecting BBB
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Yang Wang, Ruiqi Su, Jianwen Chen, Xuan Liu, Jingning Luo, Yaoqiang Lao, Ping Huang, Jinguo Shi, Caibao Jiang, Liping Liao, Jingxia Zhang