Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Yong-Liang Li, Long-Jia Yan, Hui-Xiong Chen, Ban-Kang Ruan, Pascal Dao, Zhi-Yun Du, Chang-Zhi Dong, Bernard Meunier
Monthly Archives: October 2023
Discovery of N-(2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Yongtao Duan, Yabiao Zhao, Zhenzhen Li, Zhenling Liu, Mingzhu Wang, Xuan Wang, Moran Sun, Chuanjun Song, Yongfang Yao
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Xue-Mei Zheng, Yuan-Si Chen, Yu-Juan Ban, Yu-Jie Wang, Yong-Xi Dong, Li Lei, Bing Guo, Jian-Ta Wang, Lei Tang, Hong-Liang Li, Ji-Quan Zhang
Micafungin: A promising inhibitor of UBE2M in cancer cell growth suppression
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): M.A.A. Mamun, Shuan Liu, Lijie Zhao, Lijuan Zhao, Zhong-Rui Li, Dandan Shen, Yu Zheng, Yi-Chao Zheng, Hong-Min Liu
Hydrophobicity modulation <em>via</em> the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer’s disease for potent serotonin 5-HT<sub>6</sub>R agents
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Sylwia Sudoł-Tałaj, Katarzyna Kucwaj-Brysz, Sabina Podlewska, Rafał Kurczab, Grzegorz Satała, Barbara Mordyl, Monika Głuch-Lutwin, Natalia Wilczyńska-Zawal, Magdalena Jastrzębska-Więsek, Kinga Czarnota-Łydka, Kinga Kurowska, Monika Kubacka, Ewa Żesławska, Wojciech Nitek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Partyka, Gniewomir Latacz, Anna Wesołowska, Jadwiga Handzlik
An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Ana Novak, Florian Kersaudy, Sylvie Berger, Séverine Morisset-Lopez, François Lefoulon, Carlo Pifferi, Vincent Aucagne
Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Rajeshwar Narlawar, Lutgarde Serneels, Celia Gaffric, Harrie J.M. Gijsen, Bart De Strooper, François Bischoff
Computational methods to analyze and predict the binding mode of inhibitors targeting both human and mushroom tyrosinase
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Federico Ricci, Kristina Schira, Lyna Khettabi, Lisa Lombardo, Salvatore Mirabile, Rosaria Gitto, Montserrat Soler-Lopez, Jörg Scheuermann, Gerhard Wolber, Laura De Luca
Synthesis of cannabidiol-based compounds as ACE2 inhibitors with potential application in the treatment of COVID-19
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Gabriel Vitor de Lima Marques, Daisymara Priscila de Almeida Marques, Felipe Alves Clarindo, Jesus Alberto Avendaño-Villarreal, Fabiana Sélos Guerra, Patrícia Dias Fernandes, Eduardo Nicolau dos Santos, Elena Vitalievna Gusevskaya, Markus Kohlhoff, Fabrício de Araújo Moreira, Luis Adan Flores Andrade, Flávio Guimarães da Fonseca, Jordana Grazziela Alves Coelho dos-Reis, Renata Barbosa de Oliveira
Pyrrole-thiazolidinone hybrids as a new structural class of broad-spectrum anti-infectives
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Shujauddin Ahmed, Alka Mital, Abdul Akhir, Deepanshi Saxena, Mohammad Naiyaz Ahmad, Arunava Dasgupta, Sidharth Chopra, Rahul Jain