Monthly Archives: October 2023

Tetrahydro-<em>β</em>-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Xin Chen, Jiayun Wang, Peng Zhao, Baiyun Dang, Ting Liang, Raphael R. Steimbach, Aubry K. Miller, Jia Liu, Xin Wang, Tongtong Zhang, Xiaofa Luan, Jiadong Hu, Jinming Gao

Novel spiro[pyrrolidine-2,3′-quinoline]-2′-one derivatives containing piperazine fragment as potential chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Lige Liu, Hu Wu, Yan Long, Xinlong Yang, Chuanbiao Du, Yajie Xu, Qinggang Ji

Synthesis of peptidomimetics as antibiotic adjuvants for combination with aztreonam to combat MDR <em>Pseudomonas aeruginosa</em>

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Xican Ma, Wei Guo, Xi Zhu, Zhiwen Li, Yinghong Li, Zhihao Guo, Yanxiang Wang, Jing Pang, Min Yuan, Zhenjun Li, Xuefu You, Xi Lu, Yishuang Liu, Danqing Song

Discovery of NLRP3 inhibitors using machine learning: Identification of a hit compound to treat NLRP3 activation-driven diseases

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Cheng Shi, Xiangyu Zhang, Xiaowei Chi, Yi Ran Zhou, Weiping Lyu, Tongfei Gao, Jiaxu Zhou, Yanming Chen, Chuxiao Yi, Xiaojiao Sun, Liangren Zhang, Zhenming Liu