Monthly Archives: October 2023

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Tizhi Wu, Zhiming Zhang, Guangyue Gong, Zekun Du, Yifan Xu, Sixian Yu, Feihai Ma, Xuan Zhang, Yuxiao Wang, Haoming Chen, Shiqi Wu, Xi Xu, Zhixia Qiu, Zhiyu Li, Hongxi Wu, Jinlei Bian, Jubo Wang

Discovery of novel isopropanolamine inhibitors against <em>Mo</em>TPS1 as potential fungicides with unique mechanisms

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Zhiyang Jiang, Dongmei Shi, Yitong Chen, Huilin Li, Jin'e Wang, Xinrui Lv, Yunjiang Zi, Dongli Wang, Zhijian Xu, Jiaxing Huang, Junfeng Liu, Hongxia Duan

Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling pathways

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Xiaoxue Li, Yue Hu, Bingxin He, Lingyu Li, Yu Tian, Yingjie Xiao, Hai Shang, Zhongmei Zou

Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Somaia S. Abd El-Karim, Manal M. Anwar, Nesreen S. Ahmed, Yasmin M. Syam, Samia A. Elseginy, Hanan F. Aly, Eman A. Younis, Wagdy K.B. Khalil, Kawkab A. Ahmed, Faten F. Mohammed, Maha Rizk

Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T. Supuran

Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury <em>via</em> PI3K/AKT/NF-κB axis in macrophages

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Moude Liu, Qin Tang, Qing Wang, Weixi Xie, Jinbao Fan, Siyuan Tang, Wei Liu, Yingjun Zhou, Xu Deng

Discovery of Pyrazolo[1,5-<em>a</em>]pyrimidine derivative as a potent and selective PI3Kγ/δ dual inhibitor

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Xiaofei Liang, Maoqing Deng, Fengming Zou, Ziping Qi, Chun Wang, Juan Liu, Qingwang Liu, Beilei Wang, Shuang Qi, Juan Ge, Hongwei Yu, Aoli Wang, Qingsong Liu, Jing Liu

Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Diego B. Carvalho, Pedro A.N. Costa, Gisele B. Portapilla, Amarith R. das Neves, Cristiane Y.K. Shiguemoto, Bruno I. Pelizaro, Fernanda Silva, Eliane M. Piranda, Carla C.P. Arruda, Priscyla D.M. Gaspari, Iara A. Cardoso, Pedro H. Luccas, M. Cristina Nonato, Norberto P. Lopes, Sergio de Albuquerque, Adriano C.M. Baroni