Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Shiv K. Sharma, Angel R. Schilke, Jacqueline R. Phan, Christopher Yip, Prateek V. Sharma, Ernesto Abel-Santos, Steven M. Firestine
Monthly Archives: October 2023
Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Qian Zhang, Guoyang Sun, Yuna Huang, Shanshan Cui, Tingshen Li, Lianbo Zhao, Kui Lu, Peng Yu, Yongmin Zhang, Herve Galons, Nassima Oumata, Yuou Teng
Fragment-based and structure-guided discovery of perforin inhibitors
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Jiney Jose, Ruby H.P. Law, Eleanor W.W. Leung, Dorothy C.C. Wai, Hedieh Akhlaghi, Indu R. Chandrashekaran, Tom T. Caradoc-Davies, Ilia Voskoboinik, John Feutrill, David Middlemiss, Devadharshini Jeevarajah, Tanya Bashtannyk-Puhalovich, Anna C. Giddens, Tet Woo Lee, Stephen M.F. Jamieson, Joseph A. Trapani, James C. Whisstock, Julie A. Spicer, Raymond S. Norton
A dipyridophenazine Ni(II) dithiolene complex as a dual-acting cancer phototherapy agent activatable within the phototherapeutic window
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Tukki Sarkar, Somarupa Sahoo, Suditi Neekhra, Milan Paul, Swati Biswas, Bathini Nagendra Babu, Rohit Srivastava, Akhtar Hussain
Discovery of 1,2-diaryl-3-oxopyrazolidin-4-carboxamides as a new class of MurA enzyme inhibitors and characterization of their antibacterial activity
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Reem A. Wagdy, Nader S. Abutaleb, Reem K. Fathalla, Yehia Elgammal, Stefanie Weck, Rusha Pal, Patrick D. Fischer, Christian Ducho, Ashraf H. Abadi, Mohamed N Seleem, Matthias Engel, Mohammad Abdel-Halim
Design, synthesis, and anti-respiratory syncytial virus potential of novel 3-(1,2,3-triazol-1-yl)furoxazine-fused benzimidazole derivatives
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Lu Mao, Song Wang, Ying Qu, Haixia Wang, Yifan Zhao, Chuantao Zhu, Zhongmou Zhang, Chengyun Jin, Piet Herdewijn, Feng-Wu Liu, Zhenya Wang
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Nikolaos Lougiakis, Nikolaos Sakalis, Maria Georgiou, Panagiotis Marakos, Nicole Pouli, Alexios-Leandros Skaltsounis, Eleni Mavrogonatou, Harris Pratsinis, Dimitris Kletsas
Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Nikita V. Shtyrlin, Airat R. Kayumov, Maria N. Agafonova, Marsel R. Garipov, Alina E. Gatina, Mikhail V. Pugachev, Elena S. Bulatova, Denis Y. Grishaev, Alfiya G. Iksanova, Rail M. Khaziev, Ilnur M. Ganiev, Aleksandr M. Aimaletdinov, Oleg I. Gnezdilov, Yurii G. Shtyrlin
Galantamine-memantine hybrids for Alzheimer’s disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Filippo Basagni, Jose A. Ortega, Sine M. Bertozzi, Andrea Armirotti, Maria Summa, Rosalia Bertorelli, Manuela Bartolini, Ian R. Mellor, Martina Bedeschi, Giovanni Bottegoni, Vittorio Lembo, Anna Minarini, Andrea Cavalli, Michela Rosini
Development of a NIR fluorescent probe for fluorescence-assisted EGFR-TKI applicable patients screening and drug resistance monitoring
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Xinmiao Lu, Muyu Wu, Quanyong Luo