Continuous flow reactions in the preparation of active pharmaceutical ingredients and fine chemicals

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC00418C, Feature Article
Guilherme M. Martins, Felipe C. Braga, Pedro P. de Castro, Timothy J. Brocksom, Kleber T. de Oliveira
This feature article presents an overview of continuous flow chemistry, including photoflow and electroflow technologies in the preparation of active pharmaceutical ingredients (APIs) and fine chemical intermediates.
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Enantioselective merged gold/organocatalysis

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC00114A, Highlight
Chayanika Pegu, Bidisha Paroi, Nitin T. Patil
This highlight demonstrates the state of the art in the field of the enantioselective merged gold/organocatalysis by leveraging the unique reactivity of each catalyst.
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A Fe(III) intercalated clay nanoplatform for combined chemo/chemodynamic therapy

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D3CC06205H, Communication
Ying Chen, Jing Zhai, Shiqi Wei, Aidong Tang, Huaming Yang
A nanoclay-based therapeutic system, Fe-MMT/DOX, was constructed to amplify the oxidation stress in tumor cells through the Fenton reaction, and further enhance the efficacy of DOX by interfering with DNA damage repair.
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Formation of paired Ga sites in CHA-type zeolite frameworks via a transcription-induced method

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC00186A, Communication
Open Access Open Access
Takumi Kaneko, Mizuho Yabushita, Ryota Osuga, Yugo Sawada, Kei Sato, Ben Liu, Yoshinao Nakagawa, Kiyotaka Nakajima, Keiichi Tomishige
Paired Ga sites were firstly and intentionally constructed in CHA-type zeolite frameworks via the transcription of pre-formed paired species in Ga-rich amorphous silica–gallia.
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Access to CF3-benzofulvenes via palladium-catalyzed cascade arylation/Trost–Oppolzer cyclization/double-bond isomerization

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D3CC06082A, Communication
Rami Sateesh, Jaggaraju Prudhviraj, Chiliveru Priyanka, Nagender Punna
Highly stereoselective synthesis of CF3-benzofulvenes has been achieved through a Pd-catalyzed cascade reaction involving three consecutive transformations such as arylation, Trost–Oppolzer type Alder-ene reaction, and double bond isomerization.
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Boron nanosheets as a phosphatase mimicking nanozyme with ultrahigh catalytic activity for prodrug-based cancer therapy

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D3CC05616C, Communication
Yao Lei, Qianghong Zhao, Zhou Huang, Yusha Huang, Min Wang, Lianzhe Hu, Qing Tang, Zhining Xia
The superior phosphatase-like catalytic activity of non-metallic boron nanosheets was disclosed for the first time. As a demonstration, boron nanosheets were employed for promoting prodrug conversion.
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Space-confined twin-polymerization enabling homogeneous integration of ultrafine TiO2 nanoparticles into a sulfur-doped carbon matrix for boosting lithium storage

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC00765D, Communication
Haisheng Huang, Yun Lu, Shuguang Bi, Changwang Yan, Yingkui Yang
Space-confined twin-polymerization enables homogeneous integration of ultrafine TiO2 nanoparticles into an S-doped carbon skeleton to craft a robust hetero-architecture for boosting lithium storage.
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Thioesterases as tools for chemoenzymatic synthesis of macrolactones

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC00401A, Feature Article
André R. Paquette, Jordan T. Brazeau-Henrie, Christopher N. Boddy
Thioesterases are a promising class of biocatalysts for the formation of macrocycles from linear thioester substrates.
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One-pot synthesis of azabora[6]helicene by a Schiff base forming reaction

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC00168K, Communication
Yuto Kage, Yuchuan Jiang, Namiki Minakuchi, Shigeki Mori, Soji Shimizu
Azabora[6]helicene as a new heterohelicene analogue was synthesized by a one-pot reaction of commercially available 2,6-diaminopyridine and benzo[c,d]indole-2(1H)-one and subsequent boron coordination.
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Light-activated g-C3N4 photoelectrodes with a selective molecular sieve for in vivo quantification of oxygen levels in the living mouse brain

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC00246F, Communication
Yifan Da, Qi Sun, Limin Zhang, Yang Tian
(A) Schematic illustration of the photoelectrode construction for in vivo detection in the mouse brain. (B) Schematic illustration of the mechanism for the detection of O2 by the developed photoelectrode.
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