Synthesis, Structure and Stereodynamics of Atropisomeric N-Chloroamides

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC00268G, Communication
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Aaron D. G. Campbell, Natalie J. Roper, Paul G Waddell, Corinne Wills, Casey Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong
Atropisomeric N-chloroamides were efficiently accessed by electrophilic halogenation of ortho-substituted secondary anilides. The stereodynamics of atropisomerism in these novel scaffolds was interrogated by detailed experimental and computational studies, revealing that...
The content of this RSS Feed (c) The Royal Society of Chemistry