Fluid flow-induced modulation of viability and osteodifferentiation of periodontal ligament stem cell spheroids-on-chip

Biomater. Sci., 2023, Advance Article
DOI: 10.1039/D3BM01011B, Paper
Open Access Open Access
Apurva Mishra, Ren Kai, Srividya Atkuru, Yichen Dai, Filippo Piccinini, Philip M. Preshaw, Gopu Sriram
Microfluidic spheroid-on-chip emulates physiologically relevant low fluid shear stress, resulting in improved PDLSC viability, enhanced osteodifferentiation, and uniform calcium deposition, offering new possibilities for periodontal research.
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