Hydroxynitrile lyase engineering for promiscuous asymmetric Henry reaction with enhanced conversion, enantioselectivity and catalytic efficiency

Chem. Commun., 2023, 59,12274-12277
DOI: 10.1039/D3CC02837B, Communication
Badipatla Vishnu Priya, D. H. Sreenivasa Rao, Ayon Chatterjee, Santosh Kumar Padhi
AtHNL variants displayed improved substrate scope enantioselectivity and catalytic efficiency in the asymmetric Henry reaction in the synthesis of diverse β-nitroalcohols including (R)-tembamide intermediate.
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