The combination of polymers and low molecular weight (LMW) compounds is a powerful approach to prepare new supramolecular materials – i.e. hydrogels. Here we prepare two-component hydrogels made by a well-known and biologically-active polymer, hyaluronic acid (HA), and a dipeptide-based supramolecular gelator. We undertake a detailed study of different compositions including macroscopic (hydrogel formation, rheology) and micro/nanoscopic characterization (electron microscopy, X-ray powder diffraction). We observe that the two components mutually benefit in the new material: a minimum amout of HA (1-5 mol% of COOH groups) helps to reduce the polymorphism of the LMW component leading to reproducible hydrogels with improved mechanical properties; the LMW component network holds HA without the need of irreversible covalent crosslinking. These materials have a great potential for biomedical application as, for instance, extracellular matrix mimetics for cell growth. As a proof of concept, we have observed that this material is effective for cell growth in suspension and avoids cell sedimentation even in the presence of competing cell-adhesive surfaces, which can be of interest for advanced cell delivery techniques.