![Cu-catalyzed dehydrogenative C<span class='icomoon'></span>O arylation for the synthesis of 6-methyl benzofuro[3,2-c] quinoline derivatives](https://onlinelibrary.wiley.com/cms/asset/fd580e7a-1d1f-4d1f-a1ec-7373199ea950/jhet4774-toc-0001-m.png)
Copper catalyzed dehydrogenative C—O arylation
Abstract
A novel strategy for the synthesis of 6-methyl benzofuro[3,2-c] quinoline derivatives via copper-catalyzed dehydrogenative CO arylation has been presented. Optimization studies have been carried out by varying various catalysts, bases, solvents, and other physical parameters. Keeping use of this dehydrogenative cross-coupling CO arylation reaction, a variety of bioactive building blocks like fused benzofuro quinoline heterocycles were smoothly assembled in moderate to higher yields.