Asymmetric Friedel−Crafts reaction of unsaturated carbonyl-tethered heteroarenes via vinylogous activation of Pd0-π-Lewis base catalysis

Chem. Sci., 2023, 14,10867-10874
DOI: 10.1039/D3SC03996J, Edge Article
Open Access Open Access
Bo Jiang, Wu-Tao Gui, Hao-Tian Wang, Ke Xie, Zhi-Chao Chen, Lei Zhu, Qin Ouyang, Wei Du, Ying-Chun Chen
A variety of deactivated heteroarenes tethered to an unsaturated carbonyl motif can participate in asymmetric Friedel–Crafts reactions with diverse electrophilic reagents catalysed by a chiral Pd0-complex.
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