The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe

Org. Biomol. Chem., 2023, 21,7813-7820
DOI: 10.1039/D3OB01261A, Paper
Chi-Lin Kuo, Qin Su, Adrianus M. C. H. van den Nieuwendijk, Thomas J. M. Beenakker, Wendy A. Offen, Lianne I. Willems, Rolf. G. Boot, Alexi J. Sarris, André R. A. Marques, Jeroen D. C. Codée, Gijsbert A. van der Marel, Bogdan I. Florea, Gideon J. Davies, Herman S. Overkleeft, Johannes M. F. G. Aerts
Acid β-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-β-galactosidases involved in lysosomal glycoconjugate metabolism.
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