Synthesis, characterization, and biological verification of asialoglycoprotein receptor-targeted lipopolysaccharide-encapsulated PLGA nanoparticles for the establishment of a liver fibrosis animal model

Biomater. Sci., 2023, 11,6650-6662
DOI: 10.1039/D3BM01058A, Paper
Ching-Ju Huang, Shao-Jung Hsu, Yi-Chiung Hsu, Liang-Kun Chen, Chuan Li, Hui-Chun Huang, Yu-Hsiang Lee
ALPNPs with hepatocytic targetability can specifically induce hepatic fibrosis and exhibit significantly less toxicity in organs other than the liver in comparison to free LPS after 14-day treatment.
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