Perfluoroalkyl substances (PFAS) are a class of molecules of increasing awareness and concern. Their unique properties, hazards, and complications are not always obvious, which can impede or convolute analyses, particularly at low concentrations. We have summarised “best practice” approaches for working with PFAS with the aim of enabling chemists to do so with increased confidence and safety.

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a class of hazardous pollutant that are ubiquitous in our modern world. Current research is driven by an increased awareness and concern regarding the safety of PFAS for the general population, while tightening regulations have prompted the need for detection and quantification techniques from a wide range of matrices. PFAS are a group of molecules offering unique behaviours, hazards, and complications that are not obvious or readily apparent from reading the literature. These peculiarities can impede or convolute analyses when not considered in experimental design. Drawing on the knowledge of a range of literature sources, this tutorial review looks to highlight and amalgamate the valuable suggestions and methodologies currently available to enable successful PFAS research in any laboratory.