Harnessing the power of a photoinitiated thiol–ene “click” reaction for the efficient synthesis of S-lipidated collagen model peptide amphiphiles

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01469J, Paper
Clouie Justin Aguilar, Makhdoom Sarwar, Sujay Prabakar, Wenkai Zhang, Paul W. R. Harris, Margaret A. Brimble, Iman Kavianinia
Thiolation by 2-iminothiolane followed by photoinitiated thiol–ene "click" reaction enabled the formation of S-lipidated collagen peptide amphiphiles. This methodology holds significant potential for the generation of functional peptide amphiphiles.
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