Organocatalytic Atroposelective Synthesis of Axially Chiral N,N’-Pyrrolylindoles via De Novo Indole Formation

Chem. Sci., 2023, Accepted Manuscript
DOI: 10.1039/D3SC03686C, Edge Article
Open Access Open Access
Cong-Shuai Wang, Qi Xiong, Hui Xu, Hao-Ran Yang, Yanfeng Dang, Xiu-Qin Dong, Chun-Jiang Wang
The first organocatalytic atroposelective synthesis of axially chiral N,N’-pyrrolylindoles based on o-alkynylanilines was successfully established via de novo indole formation catalyzed by chiral phosphoric acid (CPA). This new synthetic strategy...
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