Novel design of dual-action Pt(IV) anticancer pro-drugs based on cisplatin and derivatives of the tyrosine kinase inhibitors imatinib and nilotinib

Dalton Trans., 2023, 52,14110-14122
DOI: 10.1039/D3DT02030D, Paper
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Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Darren Fergal Beirne, Barbara Farkaš, Chiara Donati, Valentina Gandin, Isabel Rozas, Trinidad Velasco-Torrijos, Diego Montagner
A novel strategy for the development of Pt(IV) cisplatin-based prodrugs with tyrosine kinase inhibitors (TKi's) containing a detailed theoretical approach, synthesis, chemical characterization and preliminary results as anticancer agents and TKi's
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