Redox processes in Cu-binding proteins: the “in-between” states in intrinsically disordered peptides

Chem. Soc. Rev., 2023, 52,6595-6600
DOI: 10.1039/D3CS00443K, Viewpoint
Open Access Open Access
Enrico Falcone, Christelle Hureau
The “in-between” states (IBS) in copper bound to intrinsically disordered proteins (IDPs) are accessible due to the flexibility of IDPs and fast exchange between coordination sites, and they account for the formation of reactive oxygen species (ROS).
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