Carbonic anhydrase mimics with rationally designed active sites for fine-tuned catalytic activity and selectivity in ester hydrolysis

Catal. Sci. Technol., 2023, 13,5702-5709
DOI: 10.1039/D3CY00704A, Paper
Open Access Open Access
Foroogh Bahrami, Yan Zhao
A synthetic mimic of carbonic anhydrase shows a lower pKa value for the zinc-bound water than the natural enzyme. As a result, it is able to hydrolyze nonactivated esters at pH 7.
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