Rapid probing of glucose influx into cancer cell metabolism: using adjuvant and a pH-dependent collection of central metabolites to improve in-cell D-DNP NMR

Anal. Methods, 2023, 15,4870-4882
DOI: 10.1039/D3AY01120H, Paper
Francesca Sannelli, Ke-Chuan Wang, Pernille Rose Jensen, Sebastian Meier
Using an NMR assay with hyperpolarized glucose and NMR silent additive, we find that a recently proposed effect of pyruvate in the tumor environment is paralleled by a rerouting of cancer cell metabolism towards producing building blocks.
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