Unleashing lactoferrin’s antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats

Food Funct., 2023, Advance Article
DOI: 10.1039/D3FO02222F, Paper
Hanan H. Ahmed, Reham M. Essam, Muhammed F. El-Yamany, Kawkab A. Ahmed, Ayman E. El-Sahar
The effects of CRS on inducing depression and the beneficial effect of LF in halting depression through mitigating ROS and pro-inflammatory cytokines, restoring corticosterone, 5-HT and BDNF levels, and modulating the hippocampal PI3K/Akt/mTOR/GSK-3β pathway were studied.
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