Synthesis of pyrimidine-fused skeletons through copper-catalyzed consecutive Sonogashira coupling and aminocyclization

Org. Biomol. Chem., 2023, 21,7886-7890
DOI: 10.1039/D3OB01248D, Communication
Heng He, Jian-Quan Liu, Xiang-Shan Wang
A copper-catalyzed sequential Sonogashira coupling reaction and 5-exo-dig aminocyclization between a terminal alkyne and a 2-(2-bromophenyl)pyrimidine analog is introduced.
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