Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide

Chem. Sci., 2023, Advance Article
DOI: 10.1039/D3SC02802J, Edge Article
Open Access Open Access
Inês C. B. Martins, Anders S. Larsen, Anders Ø. Madsen, Olivia Aalling Frederiksen, Alexandra Correia, Kirsten M. Ø. Jensen, Henrik S. Jeppesen, Thomas Rades
Three polyamorphs of hydrochlorothiazide with distinct physicochemical properties were discovered. MD simulations show different dihedral angle distributions in polyamorphs I and II. Polyamorphs I and III were converted into polyamorph II.
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