Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine

Biomater. Sci., 2023, 11,6790-6800
DOI: 10.1039/D3BM00377A, Paper
Jihui Lee, Martin Beukema, Oliwia A. Zaplatynska, Conor O'Mahony, Wouter L. J. Hinrichs, Anke L. W. Huckriede, Joke A. Bouwstra, Koen van der Maaden
WIV incorporated dMNAs produced by the dispensing method reduced antigen waste by 95% compared to the centrifugation method. They also maintained the stability of WIV and elicited similar immune responses to intramuscularly (I.M.) delivered WIV.
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