Mild and scalable synthesis of phosphonorhodamines

Chem. Sci., 2023, Advance Article
DOI: 10.1039/D3SC02590J, Edge Article
Open Access Open Access
Joshua L. Turnbull, Ryan P. Golden, Brittany R. Benlian, Katharine M. Henn, Soren M. Lipman, Evan W. Miller
First reported in the 1800s, rhodamines have become indispensable fluorophores for biological imaging. We report a new, high-yielding synthesis of water soluble-rhodamines with a phosphonic acid instead of the traditional carboxylate.
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