Fibromodulin facilitates the osteogenic effect of Masquelet’s induced membrane by inhibiting the TGF-β/SMAD signaling pathway

Biomater. Sci., 2024, 12,1898-1913
DOI: 10.1039/D3BM01665J, Paper
Kai Wang, Ming Zhou, Yuanshu Zhang, Yesheng Jin, Yuan Xue, Dong Mao, Yongjun Rui
Schematic illustration of the mechanism by which an IM promotes bone formation. FMOD secreted by the IM promotes osteogenesis of BMSCs and angiogenesis of HUVECs by inhibiting the TGF-β/SMAD signaling pathway, thus facilitating bone formation.
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