Enolate addition to bicyclobutanes enables expedient access to 2-oxo-bicyclohexane scaffolds

Chem. Commun., 2023, Accepted Manuscript
DOI: 10.1039/D3CC04234K, Communication
Kyla Woelk, Kushal Dhake, Nathan D. Schley, David Leitch
We report the synthesis of 2-oxo-bicyclo[2.1.1]hexanes (2-oxo-BCHs) from bicyclobutanes (BCBs) and readily available enolate precursors. We propose this reaction proceeds via initial enolate addition to the bicyclobutane, followed by an...
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