Organocatalytic Enantioselective Desymmetrization of Enal-Tethered Cyclohexane-1,3-diones

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC00487F, Communication
Lakshmi Revati Magham, Abdus Samad, Satish B Thopate, Jagadeesh Babu Nanubolu, Rambabu Chegondi
An organocatalytic asymmetric desymmetrization of prochiral cyclohexane-1,3-diones has been demonstrated through the merging of iminium and enamine activation. The tandem annulation reaction proceeds through sequential oxa-Michael addition/intramolecular aldol reaction/[1,3]-amino oxetane...
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