Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB

Food Funct., 2023, 14,8893-8902
DOI: 10.1039/D3FO01913F, Paper
Open Access Open Access
Melanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Cláudia N. Santos, Ana Rodriguez-Mateos
We investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid from individuals at risk of dementia suing LC-MS and predicted their mechanism of transport across the BBB using in silico modelling.
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