Post-synthetic benzylation of the mRNA 5′ cap via enzymatic cascade reactions

Chem. Sci., 2023, 14,10962-10970
DOI: 10.1039/D3SC03822J, Edge Article
Open Access Open Access
N. V. Cornelissen, R. Mineikaitė, M. Erguven, N. Muthmann, A. Peters, A. Bartels, A. Rentmeister
Novel S-adenosyl-L-methionine analogues were generated enzymatically and used for regioselective benzylation of biomolecules. Applied to the mRNA 5′ cap, protein production in cells can be increased and immunogenicity altered.
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