Rh(III)-catalyzed highly site- and regio-selective alkenyl C–H activation/annulation of 4-amino-2-quinolones with alkynes via reversible alkyne insertion

Chem. Sci., 2023, 14,10971-10978
DOI: 10.1039/D3SC03987K, Edge Article
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Naohiro Hirako, Takeshi Yasui, Yoshihiko Yamamoto
A practical approach for preparing 3,4-fused 2-quinolones has been disclosed. The Rh(III)-catalyzed highly selective alkenyl C–H activation/annulation of 4-amino-2-quinolones was achieved via an unprecedented reversible alkyne insertion.
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