Transition metal-catalyzed borylation involves the incorporation of boron-containing fragment to organic molecules. Recent advancements of C_(Ar)−B bond-forming reaction include the development of new catalyst systems and boron reagents that allow for efficient transformations, as well as more versatile applications in drug synthesis and materials sciences. Representative synthetic strategies have demonstrated the ability to synthesize complex molecules through the borylative pathway as a key synthetic step.

Abstract

Transition metal-catalyzed borylation has emerged as a powerful and versatile strategy for synthesizing organoboron compounds. These compounds have found widespread applications in various aspects, including organic synthesis, materials science, and medicinal chemistry. This review provides a concise summary of the recent advances in palladium- and rhodium-catalyzed borylation from 2013 to 2023. The review covers the representative examples of catalysts, substrates scope and reaction conditions, with particular emphasis on the development of catalyst systems, such as phosphine ligands, NHC-carbene, and more. The diverse array of borylative products obtained for further applications in Suzuki-Miyaura coupling, and other transformations, are also discussed. Future directions in this rapidly evolving field, with the goal of designing more efficient, selective borylation methodologies are highlighted, too.