[{TiCl₃}₂(C₃N₃S₃H)] was designed and synthesized to study its Antidiabetic and antioxidant studies with the help of DPPH radical scavenging assay and alpha-amylase inhibition assay through both in-vitro and in-silico approaches.

[{TiCl₃}₂(C₃N₃S₃H)] (where C₃N₃S₃H is Trithiocyanuric acid) was designed and synthesized by the reaction of TiCl₄ and trithiocyanuric acid in 2:1 M ratio under stirring and refluxing condition using THF solvent. The synthesized Titanium (IV) complex was characterized by various spectroscopic techniques like FT-IR, NMR, MASS, XRD, UV–visible spectrophotometer and elemental analysis (CHNSO). Moreover, in-silico docking studies of the ligand and its Ti (IV) complex were carried out by AutoDockTools-1.5.6 to study interactions of the complex under study with the receptor protein. Afterwards, both ligand and synthesized Ti (IV)complex were screened for the antioxidant and antidiabetic potential by in-vitro method. The antioxidant potential was investigated by using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay where ligand exhibited moderate activity while Ti (IV) complex presented significant antioxidant activity. Following, alpha-amylase enzyme inhibition was investigated using iodine-starch inhibition assay. It was found that the ligand was inactive (showed no α-amylase inhibition activity) while the Ti (IV)complex was a potent α-amylase inhibitor. Furthermore, the experimentally obtained results were also complimented by the in-silico results.