Structurally divergent enantioselective synthesis of benzofuran fused azocine derivatives and spiro-cyclopentanone benzofurans enabled by sequential catalysis

Chem. Sci., 2023, 14,10768-10776
DOI: 10.1039/D3SC03239F, Edge Article
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rupkumar Khuntia, Sanat Kumar Mahapatra, Lisa Roy, Subhas Chandra Pan
We have developed a divergent approach for the catalytic asymmetric synthesis of skeletally different benzofuran fused azocine derivatives and spiro-cyclopentanone benzofurans. The methodology involves sequential catalysis: chiral H-bonding catalysis and Lewis base catalysis.
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