Design, manufacturing and testing of a green non-isocyanate polyurethane prosthetic heart valve

Biomater. Sci., 2024, 12,2149-2164
DOI: 10.1039/D3BM01911J, Paper
Open Access Open Access
Sofia F. Melo, Alicia Nondonfaz, Abdelhafid Aqil, Anna Pierrard, Alexia Hulin, Céline Delierneux, Bartosz Ditkowski, Maxime Gustin, Maxime Legrand, Bibian M. E. Tullemans, Sanne L. N. Brouns, Alain Nchimi, Raoul Carrus, Astrid Dejosé, Johan W. M. Heemskerk, Marijke J. E. Kuijpers, Jan Ritter, Ulrich Steinseifer, Johanna C. Clauser, Christine Jérôme, Patrizio Lancellotti, Cécile Oury
Non-isocyanate polyurethanes (NIPUs) were developed and tested in vitro. Prosthetic heart valves made of NIPU were designed and manufactured. NIPUs showed low thrombogenicity and the produced valves performed well in terms of hydrodynamics.
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