Org. Biomol. Chem., 2023, 21,7730-7752
DOI: 10.1039/D3OB01169K, Paper
DOI: 10.1039/D3OB01169K, Paper
Tobias Winge, Dirk Schepmann, Judith Schmidt, Constantin Daniliuc, Ernst-Ulrich Würthwein, Bernhard Wünsch
According to DFT calculations, the synthesis of spirocyclic σ1 ligands involves two aza-Michael additions or a [4 + 2] cycloaddition. Dispiro ligand with a high number of sp3 C-atoms shows promising σ1 affinity, selectivity and physicochemical properties.
The content of this RSS Feed (c) The Royal Society of Chemistry
According to DFT calculations, the synthesis of spirocyclic σ1 ligands involves two aza-Michael additions or a [4 + 2] cycloaddition. Dispiro ligand with a high number of sp3 C-atoms shows promising σ1 affinity, selectivity and physicochemical properties.
The content of this RSS Feed (c) The Royal Society of Chemistry