
The significance of fluorine atoms: The cover artwork symbolizes the importance of fluorine atoms on drug molecules, just as the red flower blossoms bring beauty and brilliance to an old tree. Although fluorine atoms greatly enhance the biological properties of pharmaceuticals and agrochemicals, fluorination reactions present persistent challenges due to their hazardous nature and limited selectivity and scalability. This review explores recently developed continuous flow techniques that addressed the challenges of fluorination reactions. The design and application of continuous flow systems specifically for fluorination reactions are discussed. More information can be found in the Review by Tsz Chun Lee, Yi Tong, and Wai Chung Fu.