One-pot synthesis of 2H-indazoles under microwave irradiation using an ionic liquid-supported copper-catalyst.

Abstract

Five-membered indazoles are recognized as a special scaffold having a broad spectrum of pharmacological properties among other heterocyclic compounds. New methods must be developed for the effective synthesis of 2H-indazole because of the exceptionally high biological activity of compounds containing a 2H-indazole core. We present the ionic liquid-supported copper-catalyzed one-pot synthesis of 2H-indazoles under microwave irradiation, continuing our ongoing investigation of the potential uses of bioactive compounds produced in the lab. The use of microwave and ionic liquid-supported catalyst makes this process greener and more highly energy efficient than the conventional reported methods. Overall, by forming consecutive C-N and N-N bonds with the help of an ionic liquid-supported copper catalyst, we have developed a novel green one-pot technique for the synthesis of the 2H-indazole motifs in very high yield.