Ligand entry pathways control the chemical space recognized by GPR183

Chem. Sci., 2023, 14,10671-10683
DOI: 10.1039/D2SC05962B, Edge Article
Open Access Open Access
Viktoria Madeline Skovgaard Kjær, Tomasz Maciej Stępniewski, Brian Medel-Lacruz, Lisa Reinmuth, Marija Ciba, Elisabeth Rexen Ulven, Massimiliano Bonomi, Jana Selent, Mette Marie Rosenkilde
The G protein-coupled receptor GPR183 utilizes two ligand entry channels: one lateral between transmembrane helices 4 and 5 facing the membrane, and one facing the extracellular environment to recognize chemically diverse ligands.
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