An efficient three-component synthesis of disubstituted 4-aryl-2-aminothiazoles was reported. The protocol features transition-metal free, short reaction time, easily available starting materials, good yields and broad substrates scope, showing potential synthetic value for the synthesis of a variety of biological or pharmaceutical active compounds.

Abstract

An efficient three-component synthesis of 4-aryl-2-aminothiazoles was reported. Phenyl-thioureas reacted with 2-bromoacetophenones to form 4-aryl-2-aminothiazoles through cyclization, and the subsequent C−N bonding with benzyl/allyl bromides gave the desired disubstituted thiazoles smoothly. The protocol features transition-metal free, short reaction time, easily available starting materials, good yields and broad substrate scope, showing potential synthetic value for the synthesis of a variety of biologically or pharmaceutically active compounds.