An efficient rhodium(III)-catalyzed C−H bond activation/allylation reaction of 3-aryl-1H-indazoles with easily available vinylethylene carbonate has been reported. A series of allyl alcohol substituted 3-aryl-1H-indazoles were obtained.
Abstract
An efficient rhodium(III)-catalysed C−H activation of 3-aryl-1-H-indazoles with easily available vinylethylene carbonate has been reported. A series of allyl alcohol substituted 3-aryl-1-H-indazoles were obtained with broad functional groups tolerance and favourable stereoselectivity. Notably, C−H and C−O bonds were selectively activated in “one pot” manner, releasing CO2 as the sole by-product and avoiding external oxidant. This protocol provides a powerful approach for the post stage C−H allylation of indazole-based substrates.