Selenium deficiency caused hepatitis in chickens via the miR-138-5p/SelM/ROS/Ca2+ overload pathway induced by hepatocyte necroptosis

Food Funct., 2023, Advance Article
DOI: 10.1039/D3FO00683B, Paper
Xinyue Sun, Wenyue Zhang, Xu Shi, Yuqi Wang, Yilei Zhang, Xiaojing Liu, Shiwen Xu, Jiuli Zhang
Selenium deficiency cause oxidative stress through upregulation of miR-138-5p targeting SelM, which disrupted Ca2+ and energy metabolic homeostasis allowing hepatocyte necroptosis leading to hepatitis in chickens.
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