Comprehensive Summary

Eight rare capnosane-type cembranoids, sarcocinerenoids A—H (1—8) and two new cage-type cembranoids sarcocinerenoids I—J (9—10) were isolated from the soft coral Sarcophyton cinereum. The 5/11 bicyclic carbon skeleton is the same in Sarcocinerenoids A—H (1—8), and they collocate distinctive oxygen rings. Sarcocinerenoids I—J (9—10) with a cage-type structure have been discovered to have an oxygen bridge and an uncommon seven-membered ring. Extensive spectroscopic investigation, X-ray diffraction analysis, estimated ECD, and DP4+ probability assessments were used to ascertain the structures of the two types of diterpenoids. Moreover, compounds 1, 4 showed promoting angiogenesis activity in zebrafish assays.