Dual functional diblock copolymer PLL₂₀-b-PBLG₂₀ was prepared by superfast and water-insensitive polymerization initiated by tetraalkylammonium carboxylate. In addition to direct antimicrobial activity, PLL₂₀-b-PBLG₂₀ also exerts a synergistic bactericidal effect against MRSA with curcumin, a plant extract with antibacterial property. Moreover, PLL₂₀-b-PBLG₂₀ successfully encapsulates curcumin to form nanoparticles via self-assembly. The combination of dual functional PLL₂₀-b-PBLG₂₀ and curcumin holds promise in combating MRSA infections.

Comprehensive Summary

The intensive use of antibiotics intensifies the development of bacterial resistance, which has become a serious problem globally. Methicillin-resistant Staphylococcus aureus (MRSA) has resulted in significant morbidity and mortality. Therefore, it is an urgent need to develop new antimicrobial drugs and administration methods. Herein, we report a dual functional diblock copolymer PLL₂₀-b-PBLG₂₀, which was prepared by superfast and water-insensitive polymerization on N-carboxyanhydrides (NCA) initiated by tetraalkylammonium carboxylate. In addition to direct antimicrobial activity, PLL₂₀-b-PBLG₂₀ also exerts a synergistic bactericidal effect against MRSA with curcumin, a plant extract with antibacterial property. Moreover, PLL₂₀-b-PBLG₂₀ successfully encapsulates curcumin to form nanoparticles via self-assembly. The combination of dual functional PLL₂₀-b-PBLG₂₀ and curcumin holds promise in combating MRSA infections.