Ligand substitution reactions afford oxaliplatin-based platinum(IV) complexes bearing axial alkoxido ligands

Inorg. Chem. Front., 2023, 10,6058-6066
DOI: 10.1039/D3QI01562A, Research Article
Zoufeng Xu, Long Lin, Binbin Fu, Fu-Ping Huang, Qiyuan Zhou, Guangyu Zhu, Zhigang Wang
Oxaliplatin-based platinum(IV) complexes bearing axial alkoxido ligands were obtained by substituting the trifluoroacetato ligand. These complexes exhibit enhanced stability and reduced cytotoxicity compared to their carboxylated platinum(IV) analogues.
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