Lead is an environmental pollutant that has been present for a long time and has harmful effects on human health. The essential task of protecting public health requires sensitivity and selectivity in monitoring and removing Pb²⁺ from the environment. NH₂-Al-MOF was utilized to create a chemical sensor that can quickly detect Pb²⁺ ions. By combining the Al–metal–organic framework (MOF) with 2-Acetyl-4-methylpyridine, the 2A4MP=N-Al-MOF sensor was developed. The NH₂-Al-MOF and 2A4MP=N-Al-MOF sensor were characterized by X-ray photoelectron spectroscopy (XPS), Brunner–Emmet–Teller (BET), X-ray diffractometer (XRD), Fourier transform infrared (FT-IR), and scanning electron microscopy (SEM). Characterization results indicate that 2-Acetyl-4-methylpyridine was effectively incorporated into the Al-based MOF, and the 2A4MP=N-Al-MOF sensor's pore structure is primarily made up of mesopores. To determine the optimal conditions for detecting Pb²⁺ ions using the 2A4MP=N-Al-MOF sensor via fluorescence measurement, several experimental studies have been carried out. A steady spectroscopic signal can be achieved with a sensor that has a response time of below 30 seconds. According to ICH guidelines, the suggested methods underwent validation for LOD, LOQ, linearity, and precision. The results show that the 2A4MP=N-Al-MOF chemosensor has a high sensitivity and selectivity toward the Pb²⁺ analyte, with a detection limit of 0.171 ppm and a linear range of 0.0–2.0 ppm. The 2A4MP=N-Al-MOF chemosensor also exhibited good reproducibility, with a relative standard deviation of less than 3%. As a result, the Pb²⁺ ions were sensitively and selectively identified in various environmental water samples using the 2A4MP=N-Al-MOF sensor.

The interactions of Cu (II) complexes with Schiff bases as ligands and DNA (ct-DNA/Salmon Sperm DNA) were investigated using electronic absorption, spectroscopic fluorescence method, and viscosity measurements and investigated by electrophoretic mobility shift assay. Cytotoxicity analyses were performed on human colorectal carcinoma HCT-166 and healthy lung fibroblast MRC-5.

Cancer remains one of the most common diseases worldwide in terms of deaths and claims many lives every day. Transition metal complexes are candidates in the development of anticancer drugs, with cisplatin being used in chemotherapy worldwide. Copper, an endogenous metal, is known for its pronounced redox potential and nucleophilicity, especially when bound to biological molecules. Cu (II) complexes were synthesized containing ethane-1,2-diamine as amine moiety and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione, pentane-2,4-dione and/or 1,1,1-trifluoropentane-2,4-dione or 1,1,1-trifluoropentane-2,4-dione and/or 1-phenylbutane-1,3-dione as β-diketone moiety. Standard methods were used to confirm the structure of complexes 1–6. X-ray crystal structure analysis characterized complex 1 containing the ligand ethane-1,2-diamine and pentane-2,4-dione. The interactions of complexes 1–6 with calf thymus DNA (ct-DNA) were followed by electronic absorption and fluorescence spectroscopy methods and by viscosity measurements. In contrast, interaction with Salmon Sperm DNA was investigated using the electrophoretic mobility shift assay. The results indicate a moderate affinity of complexes 1–6 for binding to DNA. Gel electrophoresis also shows that the studied complexes have a concentration-dependent interaction with DNA. Spectroscopic fluorescence techniques were used to monitor the affinity of the complexes for bovine serum albumin (BSA). Complexes 1–6 showed satisfactory binding ability for BSA. Cytotoxicity analyses were performed on the human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showing that complex 5 exhibited selectivity between cancer and normal cells, which is critical for drug development.

Preparation of metal complexes of Girard-T hydrazones Geometry optimization, thermal degradation, and biological Studies of investigated compounds 3D molecular docking interaction of GT.O ligand towards the inhibitor to MCF-7 through a π–π stacking between aromatic ring and PHE856

This article details the synthesis of new Girard-T reagent ligands. Condensation of 2-hydroxyacetophenone or 2-acetyl-thiophene with Girard-T reagent results in new hydrazone ligands. The interaction of these Girard-T hydrazones with transition metal chlorides, like Au (III), Ru (III), Pd (II), and Pt (II), produces different complexes. Elements and spectrum analyses (IR, UV–Vis, EI-mass, and ¹H NMR) were used to characterize the isolated solid complexes, as well as conductimetric and magneto-chemical studies. Metal complexes can have different geometrical configurations, including square planar and octahedral coordination. The DMOL³ method, which is a part of the Material Studio package, was also utilized for structure optimization. Horowitz–Metzger and Coats–Redfern methods were utilized to calculate the various thermodynamic and kinetic parameters. The ligands and the complexes of their metal were evaluated for anticancer activity against carcinoma cervix (Prostate) and the mammary gland female breast (MCF-7) cell line having cancer, with promising results. Among these compounds, the Ru (III) and Pt (II) complexes' anticancer activity against (MCF-7) cell lines, comparable with that of 5-fluorouracil were carried out and their interactions were performed by molecular docking simulations against MCF-7 (PDB ID: 3W2S) receptor.

This study shows that the particle size of ZIF-67 can be controlled by adjusting the reactant concentration, enabling manipulation of the electrochemical properties as a sulfur host.

To improve the electrochemical performance of Li-S batteries, sulfur composites are prepared through sulfur's melt-diffusion into porous materials such as metal organic frameworks (MOFs). MOFs are porous nanocrystalline materials consisting of metal ions and organic ligands. Due to their high porosity, specific surface area, and easily controllable porous structure, MOFs and their derivatives are considered useful materials for holding sulfur. Herein, the effect of the concentration of the reactants on the particle diameter distribution of ZIF-67 is studied, and the performance of the product as a sulfur host for Li-S battery cathode is evaluated. ZIF-67 was prepared by regulating the Co²⁺ concentration in solution from 10 to 250 mM, with a constant mole ratio between Co²⁺ and the organic ligand. Cyclovoltammetry, galvanostatic charge–discharge, and rate capability tests were performed to electrochemically characterize each sample as a sulfur host for Li-S battery cathodes. MeZ-50 mM, prepared with 50 mM Co²⁺ ion solution, had the smallest particle diameter (591 nm). The sulfur cathode utilizing MeZ-50 mM afforded the best electrochemical performance (883.7 mAh g_S ⁻¹). This study demonstrates that the particle size of ZIF-67 can be controlled by adjusting the reactant concentration, enabling manipulation of the electrochemical properties as a sulfur host.

The CC@ZrO₂ green catalyst was created by immobilizing a chlorophyllin copper complex onto ZrO₂ nanoparticles under mechanical conditions. The resulting catalyst demonstrated exceptional efficacy in generating different types of thioether derivatives.

The synthesis of organosulfur compounds gained specific interest in the interference of organic chemistry and chemical biology. Copper chlorophyllin (CC) is a bio-based copper complex that facilitates the synthesis of organosulfur compounds through the thioetherification reaction. The current paper deals with the immobilization of CC on the ZrO₂ nanoparticles (CC@ZrO₂) and its application in the one-pot thioetherification of alkyl and aryl halides using thiourea, an alternative to the bad-smelling thiols. After the characterization of CC@ZrO₂ with different analytical techniques such as FT-IR, TGA, XPS, N₂ adsorption/desorption, XRD, ICP, and FESEM, the catalytic activity of the prepared CC@ZrO₂ was evaluated in the synthesis of different types of thioether derivatives. Good to excellent yields, high reusability, and reproducibility made this cost-effective approach a benchmark in C–S cross-coupling reactions.

The synthesized composite material shows lower overpotential of 187 mV as well as lower Tafel slope value than the individual materials. It also shows excellent stability, which makes it suitable as electrocatalyst for water splitting.

It is essential to produce oxygen evolution reaction (OER) electrocatalysts, which are active and enduring for water electrolyzers. In order to create the effective OER, new chromium telluride/graphitic carbon nitride (gCN/CrTe) is produced via simple hydrothermal method. In this case, catalyst super hydrophilic surface is developed by the addition of 10% gCN nanosheets that can optimize the revelation of active sites and encourage the mass dispersion. Due to the robust contact among CrTe and gCN, which causes a lattice strain and an increase in the electron density around Cr sites, regulating the bonding between the catalyst and chemical intermediates. The improved 10% gCN/CrTe nanocomposite offers not only a good endurance but also by the highest mass activity. The synthesized 10% gCN/CrTe electrocatalysts provided low overpotential around 187 mV for OER to achieve a current density of 10 mA/cm² in alkaline media with 51.0 h of long durability. Paving the way for innovative applications, this will enable the manipulation of advanced materials' fundamental properties at the atomic scale.

2-Acetyl-6-iminopyridine ligand-supported cobalt catalyst is highly active in isoprene, myrcene, and butadiene catalytic polymerization. The catalytic performances are stable against temperature, cocatalyst feeding, and monomer ratio.

Cobalt complexes carrying 2-acetyl-6-iminopyridine ligand are synthesized and characterized. Single-crystal X-ray diffraction reveals the cobalt ion is chelated with two nitrogen atoms and an acetyl oxygen atom additionally. A significant prolonged Co–O distance (2.3960(57) Å) is found, indicative of a labile character. Activated by diethylchloroaluminum, all complexes show high conversion rates for isoprene and myrcene polymerizations, affording cis-1,4/3,4 regulated 1,3-diene polymers. The polymerization of butadiene, interestingly, gives predominant cis-1,4 selectivity (>99.2%) with moderate activity. The substituent at ortho-position of arylimine plays a minor role in controlling activity and selectivity as well as the molecular weight of the resultant polymers. The properties of resultant poly(1,3-diene)s are stable even in a wide range of operational conditions, such as [Al]/[Co] varied from 20 to 600, temperature spanning from 0°C to 60°C, and monomer–catalyst ratio from 1000 to 4000. These additional benefits of minimum fluctuation in catalytic performances may be suitable for industrial polymerization process.

Meso-1,2-diphenyl-1,2-ethylenediamine was reacted with salicylaldehyde derivatives, copper(II) perchlorate, and pyridine to produce various four-coordinated heteroleptic [Cu (SBⁿ)(py)]ClO₄ (n = 1–4) complexes. Ligand exchange of the monodentate pyridine with bidentate 2,2′-dimethyl-4,4′-bithiazole (BTZ) produced other new series of five-coordinated [Cu (SB^na)(BTZ)]ClO₄ complexes. Elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), and ultraviolet–visible (UV–Vis) spectroscopy were used to identify the complexes. The crystal structures of 1a and 2a were also determined by single-crystal X-ray crystallography (SCXRC). The inhibitory potential of these complexes against SARS-CoV-2 and its omicron variant main proteases (PDB IDs: 6LU7 and 7TLL, respectively) was investigated by means of molecular-docking modeling. According to the estimated free binding energy (EFBE), the order of binding energies were (3) > (3a) > (1a) > (1) > (2a) > (4a) > (4) > (2) for 6LU7 and (1a) > (3) > (1) > (4) > (2) > (4a) > (2a) > (3a) for 7TLL. The complexes (1a) for 6LU7 and (3) for 7TLL with electronegative Br substituents were at the top of the series and had the most negative ΔG_binding. The EFBE of four conventional corona-virus medicines, that is, remdesivir, hydroxychloroquine, dexamethasone, and AstraZeneca were also obtained and compared with the synthesized complexes. The EFBE of the complexes were comparable to standard drugs.

In this work, an efficient, novel, retrievable, and magnetic heterogeneous nanocatalyst, Fe₃O₄@CPTMS@Asp@Ni was successfully fabricated using Fe₃O₄ nanoparticles as the core that were coated with surfactant and 3-chloropropyltrimethoxysilan and deposited asparagine and nickel metal that can be used in multicomponent reactions for the synthesis of acridines derivatives with high yield in short reaction times. The virtue of obtained nanocatalyst was identified using transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction analysis, energy dispersive X-ray, Brunauer–Emmett–Teller, vibrating sample magnetometry, Raman, and thermogravimetric analysis. The X-ray diffraction analysis studies demonstrate that the average crystallite sizes of the prepared nanocatalyst are estimated to be about 45.4 nm. Also, the vibrating sample magnetometry measurement shows saturation magnetization values (Ms) of 7 emu/g for Fe₃O₄@CPTMS@Asp@Ni nanocatalyst. Also, after the synthesis steps, the application of the prepared nanocatalyst in the preparation of acridine-1,8(2H,5H)-diones has been investigated. Then to evaluate and assess the efficiency of the nanocatalyst as mentioned above, and its effect on the synthesis of divergent acridines via a one-pot, three-component condensation reaction of cyclic 1,3-dione, aryl glyoxal, with ammonium acetate in the water as green solvent was studied. Also, when investigating the reusability of this catalyst, it was observed that Fe₃O₄@CPTMS@Asp@Ni nanocatalyst could be reused at least five times without losing its efficiency. High efficiency, outstanding yields in quick intervals, easy separation using a magnetic field, and possessing reusability are significant benefits of the attained nanocatalyst.

We propose to use the platinum(II) C,N-cyclometalated complex (PCC) to catalyze the hydrosilylation and dehydrocoupling reactions of high molecular weight polysiloxanes at elevated temperatures (above 100°C). PCC was prepared via a three-step procedure consisting of the 2-hydrazinopyridine synthesis, its treatment with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde, and coupling of the obtained product with cis-[PtCl₂(CNXyl)₂]. This complex exhibits thermal stability up to 150°C even at heating in air. PCC allows carrying out the cross-linking of vinyl-terminated polydimethylsiloxane (V-PDMS) and polymethylhydrosiloxane (PMHS) by hydrosilylation, as well as PMHS dehydrocoupling cross-linking at 150 and 120°C, respectively. The coupling (cross-linking) patterns were successfully confirmed by ¹H, ¹³C, and ²⁹Si solid-state NMR spectroscopy. The thermal and swelling characteristics and the transparency of the obtained silicone materials indicate the absence of aggregation of platinum particles.