Publication date: 15 November 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 96
Author(s): Qiang Zhang, Ping Zou, Meixuan Zhu, Dan Sui, Shaoming Wang, Zhiwei Hu, Yang Wang, Lijia Jing, Jian Zheng
Category Archives: Bioorganic & Medicinal Chemistry Letters
Synthesis and preliminary biological evaluation of a novel <sup>99m</sup>Tc-labeled small molecule for PD-L1 imaging
Publication date: 15 November 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 96
Author(s): Dandan Zhu, Xiang Xu, Pei Zou, Yaling Liu, Hongyong Wang, Guoqing Han, Chunxiong Lu, Minhao Xie
Specific imaging of intracellular hydrogen sulfide by a positively charged NIR fluorescent probe
Publication date: 15 November 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 96
Author(s): Jianjun Fang, Xuemei Dong, Lixin Sun, Jie Sun, Chengjun Dong, Rongchen Wang, Chunchang Zhao
Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Yujie Wang, Keshi Xu, Hongchun Liu, Wei Zhang, Chun Hu, Yingxia Li
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Ahmed Fnaiche, Léa Mélin, Narjara González Suárez, Alexis Paquin, Victoria Vu, Fengling Li, Abdellah Allali-Hassani, Albina Bolotokova, Frédéric Allemand, Muriel Gelin, Philippe Cotelle, Simon Woo, Steven R. LaPlante, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Jean-François Guichou, Borhane Annabi, Alexandre Gagnon
Synthesis of mizoribine prodrugs and their <em>in vivo</em> evaluation as immunosuppressive agents
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Ling-Jie Gao, Yuan Lin, Steven De Jonghe, Mark Waer, Piet Herdewijn
Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Albert W. Garofalo, Jacob Schwarz, Kerry Zobel, Claudia Beato, Silvia Bernardi, Federica Budassi, Laura Caberlotto, Peng Gao, Cristiana Griffante, Xinying Liu, Marco Migliore, Feifei Qiao, Fabio Maria Sabbatini, Anna Sava, Mingliang Zhang, Holly J. Carlisle
Discovery of a non-covalent ligand for Rpn-13, a therapeutic target for hematological cancers
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Cody A. Loy, Christine S. Muli, Eslam M.H. Ali, Dan Xie, Mostafa H. Ahmed, Carol Beth Post, Darci J. Trader
Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Takashi Tsuji, Honoka Tsunematsu, Masaki Imanishi, Masaya Denda, Koichiro Tsuchiya, Akira Otaka
Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Suleyman Akocak, Nebih Lolak, Simone Giovannuzzi, Claudiu T. Supuran